Promen

A sex-change drug of surprising potency, Promen can change human men into women for as long as the dosage is kept up – and one dose a month is sufficient.

However, no matter long the user has been taking it, withdrawal undoes all its effects, reverting the user to their original biological sex.

Related Drugs: Profem and Rokyn.

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Origin: Legion of Super-Heroes by Keith Giffen, Mary Bierbaum and Tom Bierbaum.